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Abstract. The Krüppel-like factor (KLF) family of transcription factors plays an important role in differentiation, function and homeostasis of many cell types. While their role in lymphocytes is still being determined, it is clear that these factors influence processes as varied as lymphocyte quiescence, trafficking, differentiation and function.
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Abstract. Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of KLFs in the kidney with a focus on potential pharmacological modulation/therapeutic applications of these KLF proteins. KLF2 is critical to maintaining endothelial barrier.
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Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of KLFs in the kidney with a focus on potential pharmacological modulation/therapeutic applications of these KLF proteins.
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1. ). Klf family members contain three conserved DNA-binding C 2 H 2 zinc fingers that recognize similar consensus sites ( 2. ). The N-terminal domains of the various Klfs vary, and these different domains mediate different molecular functions. Some Klfs function predominantly as activators, such as Eklf/Klf1 (erythroid Klf) ( 3.
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Strikingly, loss of function of both klf-1 and klf-3 abolished lifespan extension in the eat-2(ad1116) and food dilution on solid agar (sDR) models of dietary restriction as well as in the daf-2.
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Büyük Beden Tesettür Kibar Uzun Elbise KL795 OLASTORM
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Büyük Beden Zarih ve Şık Abiye Elbise KL59 OLASTORM
The mammalian Krüppel-like factor (KLF) family of zinc finger transcription factors has recently received increased attention. There are >15 known family members at present, and despite initial expectations that they would have redundant functions, they, in fact, have individually important biological functions, as shown by gene knockout studies (eg, KLF2, KLF4, and KLF5).
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The Krüppel-like factors (KLFs) belong to a family of zinc-finger containing transcription factors. KLFs regulate diverse biological processes in mammalian tissues, including cell proliferation, differentiation and survival, and tissue development. KLFs are also crucially involved in the maintenance of systemic and tissue homeostasis ( 1, 2 ).
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Büyük Beden Güpürlü Uzun Abiye Elbise KL8756 OLASTORM
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Krüppel-like factor 10 (KLF10), originally named TGF-β (Transforming growth factor beta) inducible early gene 1 (TIEG1), is a DNA-binding transcriptional regulator containing a triple C2H2 zinc finger domain. By binding to Sp1 (specificity protein 1) sites on the DNA and interactions with other regulatory transcription factors, KLF10.
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Krüppel-like factors (KLFs) are a family of transcription factors characterised by zinc-finger structures at the C-terminal. They play the key roles in cell proliferation, differentiation, and migration, as well as in embryonic development. They have been widely expressed in multiple systems in vivo, and their dysregulation is closely associated with a variety of human diseases. Glycolipid.
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KLF is a family of transcription factors with a zinc-finger DNA-binding region at the C-terminus. For example, both KLF5 and KLF15 have been reported to be important for adipocyte function and.